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KMID : 0383819900370010066
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Tuberculosis and Respiratory Diseases
1990 Volume.37 No. 1 p.66 ~ p.73
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Superoxide Generation by Bronchoalveolar Lavage Cells in Patients with Tuberculosis
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박춘식/Choon Sik Park
김용훈/우준희/정연태/어수택/Yong Hun Kim/Jun Hee Woo/Yeon Tae Chung/Soo Taek Uh
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Abstract
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Macrophage can kill tuberculous bacill through the toxic action of oxygen radicals
after activation by lymphokines released from sensitized lymphocyte to tuberculous
antigens.
In the lesion of the patients with tuberculosis, the cytoxic ability of macrophage may
be decreased from the fact that function of peripheral blood monocyte decreased in
terms of migration, antigenspecific lymphoblast transformation and expression of immune
associate antigen in patients with tuberculosis.
In order to search for the functional status of macrophage located in the tuberculous
lesion, we measured the amount of superoxide radical generated by bronchoalveolar
lavage (BAL) cells obtained from the tuberculous lesion.
The results were 1) Generations of superoxide was low by the same number of BAL
cells in patients with tuberculosis when compared with those in control group (p<0.05)
but the amount of superoxide corrected with the percentages of macrophage in patients
with the was same as those in control group.
2) The total number of BAL cells and the percentage of lymphcocyte and neutrophil
were markedly higher than those of control group (p<0.05).
3) Phorbol myrisate acetate enhanced the generation of superoxide in patients with
tuberculosis to the same extent with those in control group and PPD more enhanced the
generation of superoxide in patients with tuberculosis than those in control group
(p<0.05).
4) Total generation of superoxide by BAL cells obtained from tuberculous lesion was
a little higher than those of control (p>0.05).
In conclusion, the capacity to generate superoxide radical by the constant number of
BAL cells decreased in patients with tuberculosis probably due to extracellular influence
and the total amount of local synthesis of superoxide was a little higher in patients with
tubercuiosis than that in control group due to the increased number of infiltrating cells
in tuberculous lesion.
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